Ameliorating Effects of Geumnyeonyijin-tang Water Extract on Obesity-Induced T2DM and Related Complications in Mice

Objective: The aim of this study was to compare the effects different doses Geumnyeonyijin-tang (GNYJT) water extracts with those metformin (250 mg/kg) in mild diabetic-obese mice.Methods and Results: 48 mice were divided into 1 normal pellet diet (NFD) group 5 high-fat (HFD) groups. At end 12 weeks oral administration or GNYJT (400, 200, or100 mg/kg), evaluated. HFD control showed noticeable increases body weight, adipose tissue density, fat pad weight periovarian abdominal wall, insulin, blood glucose, HbA1c levels, decreases serum HDL levels. Increases dorsal pad, regions steatohepatitis, adipocyte hypertrophy, hepatocyte hypertrophy also discovered. a decline glucose levels elevation hepatic gluconeogenesis, suggesting an HFD-induced AMPK downregulation related dysregulation, as well lipid metabolism obese insulin-resistant type II diabetes, dyslipidemia, oxidative stress diabetic hepatopathy (non-alcoholic fatty liver disease, NAFLD).Conclusion: Assessment key parameters for inhibition diabetes complications HFD-fed demonstrated that have favorable ameliorating effects. effect manifested through stimulation upregulation enzyme activities expression metabolism-related genes. Therefore, appropriate dosages could be promising new preventive candidate controlling complications. Further screening biologically active compounds, elucidation detailed mechanisms, more animal studies are warranted.